Book Hotels in O Brien, FL
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Top O Brien hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
obrien FL
A gym is featured at this vacation home, along with a garden and laundry facilities. There's fun for all ages with a playground and an arcade/game room, and ...
Comfortable beds, soft sheets and lots of towels. Our week long stay was a delight and we were able to enjoy a truly relaxing trip to visit family and friends nearby. Christine and Tony were very responsive and even brought a cooler over from their home for us to use during our stay. We are looking ...
Reviewed on Nov 17, 2025

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
1699 NE Co Rd 337 High Springs FL
$139 nightly
The price is $153 total per night from Dec 14 to Dec 15
$153 total
Dec 14 - Dec 15
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
Room very clean , super comfortable . me and my wife had an amazing time . thanks
Reviewed on Dec 9, 2025

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD Alachua FL
Fully refundable
$113 nightly
The price is $127 total per night from Dec 14 to Dec 15
$127 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Great Property for Families
Reviewed on Dec 10, 2025

Hampton Inn & Suites Lake City
450 SW Florida Gateway Drive Lake City FL
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Dec 21 to Dec 22
$98 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
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Reviewed on Dec 1, 2025

Comfort Suites Lake City
3690 W Us Highway 90 Lake City FL
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $116 total per night from Dec 14 to Dec 15
$116 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Very nice customer service
Reviewed on Dec 4, 2025

Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $113 total per night from Jan 4 to Jan 5
$113 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Clean, convenient
Reviewed on Dec 4, 2025

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Dec 14 to Dec 15
$98 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Staff was so friendly and helpful. Rooms were very comfortable.
Reviewed on Dec 9, 2025

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Dec 15 to Dec 16
$105 total
Dec 15 - Dec 16
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
The property was very well situated, close to the highway and gas stations. The food for breakfast was very well appointed. The check-in and checkout process was very simple.
Reviewed on Dec 9, 2025

Motel 6 – Lake City, Fl – Medical Center
3340 W US Highway 90 Lake City FL
Fully refundableReserve now, pay when you stay
$52 nightly
The price is $59 total per night from Dec 14 to Dec 15
$59 total
Dec 14 - Dec 15
Total with taxes and fees
Staff at the 24-hour front desk can provide around-the-clock assistance. Take advantage of the free self parking.
Steven and the rest of the staff here provided the best customer service. I will 100% stay here again.
Reviewed on Dec 7, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent O Brien hotel reviews by fellow wanderers

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Great Property for Families "
A verified traveler from Plantation stayed at Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
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