Book Hotels in O Brien, FL

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Top O Brien hotels

Pet-Friendly Florida Escape w/ Patio & Fire Pit!

Pet-Friendly Florida Escape w/ Patio & Fire Pit!

O'Brien
This vacation home featured laundry facilities and barbecue grills.
"Really nice pet-friendly place with a cool screened in patio and fire pit. Our family loved it."

Reviewed on Jul 30, 2025

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Pet-Friendly Florida Escape w/ Patio & Fire Pit!
Postcard Cabins Gilchrist Springs

Postcard Cabins Gilchrist Springs

2 out of 5
1699 NE Co Rd 337, High Springs, FL
$154 nightly
The price is $169 total per night from Aug 17 to Aug 18
$169 total
Aug 17 - Aug 18
Total includes taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
"Para descansar y alejarte del mundo real en total confort, paz, limpieza y conectado a full con la naturaleza pero con comodidades que elevan el camping a otro nivel"

Reviewed on Aug 10, 2025

Postcard Cabins Gilchrist Springs
MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

O'Brien
$371 nightly
The price is $404 total per night from Aug 20 to Aug 21
$404 total
Aug 20 - Aug 21
Total includes taxes and fees
A garden, express check-in, and express check-out are available at this vacation home. Laundry facilities and barbecue grills are also provided.
"We absolutely enjoyed our stay. We had 1 small issue that was quickly resolved by the host. The place was conveniently located close to royal spring and that boat ramp. The decks on this place was massive. The river deck was nice to sit on as well. We will definitely be back if they will have ..."

Reviewed on Jul 23, 2025

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
Comfort Suites Lake City

Comfort Suites Lake City

2.5 out of 5
3690 W Us Highway 90, Lake City, FL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Aug 24 to Aug 25
$105 total
Aug 24 - Aug 25
Total includes taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Great hotel!"

Reviewed on Aug 14, 2025

Comfort Suites Lake City
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD, Alachua, FL
Fully refundable
$110 nightly
The price is $124 total per night from Aug 25 to Aug 26
$124 total
Aug 25 - Aug 26
Total includes taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Great hotel! I recommend it !"

Reviewed on Aug 12, 2025

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court, Lake City, FL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $107 total per night from Aug 17 to Aug 18
$107 total
Aug 17 - Aug 18
Total includes taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Just passing through
"One night stay great place just off I-75."

Reviewed on Aug 13, 2025

Tru by Hilton Lake City
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr, Lake City, FL
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $91 total per night from Aug 24 to Aug 25
$91 total
Aug 24 - Aug 25
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Very helpful and friendly staff especially at the checkin counter"

Reviewed on Aug 14, 2025

Best Western Plus Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE, Lake City, FL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Aug 17 to Aug 18
$105 total
Aug 17 - Aug 18
Total includes taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Check in was quick and easy. There was no remote for the TV but the front desk was prompt in getting that fixed right then and there. Plenty of restaurants nearby along with stores. Very convenient when traveling along Interstate 75. Setback in a quiet location."

Reviewed on Aug 10, 2025

La Quinta Inn & Suite by Wyndham Lake City
Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG

3 out of 5
213 Sw Commerce Dr, Lake City, FL
Fully refundable
$83 nightly
The price is $93 total per night from Sep 1 to Sep 2
$93 total
Sep 1 - Sep 2
Total includes taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Always a great experience. 10/10. Friendly and helpful staff. Nice rooms, great location and easy parking."

Reviewed on Aug 11, 2025

Holiday Inn & Suites Lake City by IHG
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in O Brien?
Family vacations are where treasured memories are made, but traveling with youngsters can be tricky. These kid-friendly O Brien hotels offer perks designed to keep adventurers of all ages relaxed and happy: The whole team will enjoy staying at Cozy OBrien Home w/Fire Pit & Patio Near 3 Rivers. A firepit and free WiFi are just a few of the things that help make this hotel an attractive option. 1 ½ Acre OBrien Home with Fire Pit - Near River! is another top place to stay. After a big day of exploring, return to your comfy room and amenities like a deck and a firepit.
Where can I find cheap hotels in O Brien?
At Travelocity you'll find really nice hotels in O Brien at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near O Brien rather than in O Brien. We may find you even better rates, too.
How do I find the best O Brien hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in O Brien then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in O Brien?
The cheapest hotel in O Brien is $91. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in O Brien?
There are 319 hotels in O Brien on Travelocity.
What are the best hotels in O Brien?
O Brien has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in O Brien for you!
When is the best time to visit O Brien?
If you want the joy of a fun-filled trip in peak season, visit O Brien during March, November and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, April and June.
When is the cheapest time to stay in O Brien?
Based on historic data is usually the cheapest month to visit O Brien. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in O Brien?
There are multiple hotels in O Brien that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to O Brien. We have plenty of kid-friendly hotels in O Brien to choose from on Travelocity!
Why book a hotel in O Brien through Travelocity?
Because we have the top hotels in O Brien! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in O Brien on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent O Brien hotel reviews by fellow wanderers

Comfort Suites Lake City

Comfort Suites Lake City

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Great hotel!"
A verified traveler stayed at Comfort Suites Lake City
Comfort Suites Lake City
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